Researchers began to work on compounds that stifle TMPRSS2s ability to interact with the viral protein. JAMA Otolaryngol. Mutations in spike allow the virus to evade the immune system as well as therapies designed to target it. PubMed Nature 602, 676681. Approval of the study by the German Federal Institute for Drugs and Medical Devices (BfArM) was given on 3rd February 2021. CAS Vitiello, A., Ferrara, F., Troiano, V. & La Porta, R. COVID-19 vaccines and decreased transmission of SARS-CoV-2. The number of possibly and probably related adverse events was comparable between treatment groups (supplementary Table S6), and no safety concerns regarding the treatment regime were raised. https://doi.org/10.6026/97320630016236 (2020). Promising nose spray could prevent and treat COVID-19 Trials under way to see if Boots nasal spray can prevent Covid-19 A Boots nasal spray for cold and flu has shown positive results during testing to see if it could help tackle coronavirus infections. Viruses 13, 895. https://doi.org/10.3390/v13050895 (2021). Early intervention with azelastine nasal sprays reduces viral load in SARS-CoV-2 infected patients. To evaluate the total load during the study, AUC was calculated using a linear equation. This trial was conducted at the Department of Otorhinolaryngology, Head and Neck Surgery of the Faculty of Medicine of the University of Cologne, Germany. Ghahremanpour et al. Overall, the current results are encouraging; however, further studies should be carried out to strengthen the findings, and treatment should be extended to other age and risk groups and cover individuals with different levels of symptom severity. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made.
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