(And myself.) Otolaryngol Head Neck Surg. Afirma GSC: Better as One Joshua Klopper, MD March 28, 2023 - Afirma Recently I change insurance and in doing so, my new doctor ordered a ultrasound which showed the nodule and he felt it was nothing to worry about. This site needs JavaScript to work properly. Patients with thyroid nodule biopsies with indeterminate cytology results were chosen for additional genetic testing; the Afirma GEC (during the period February 2, 2011July 11, 2017) or the Afirma GSC (during the period July 11, 2017December 19, 2018). So frustrating!! The Afirma gene sequencing classifier (GSC) performs better in indeterminate thyroid nodules than the Afirma gene expression classifier (GEC). It mentions possible microcalcification, which has never come up before. I have never really loved my endo, and have always felt like she was pressuring me into surgery. Thank you. Hello, new here and confused, anxious and a bit worried. I'm a 39 years old male. I had a biopsy for 4 nodules 2 mos ago. Thyroid. Therefore, a new version of the Afirma test was created called a gene sequencing classifier (GSC) to better predict thyroid cancers in indeterminate nodule while still being able to rule out cancer in benign nodules. THE FULL ARTICLE TITLE I'm a foodie who has always struggled with weight, but I also exercise so I'm always just plump but in otherwise decent health. Don't want to gain weight or feel less optimal then I am now. However, I was not informed of this. She then tells me that at a recent conference, there was a lot of discussion of Afirma, and the general consensus seemed to be that it was good at detecting papillary cancer, but not necessarily follicular. He also said that what the Afirma pathologist and representatives told me that I have a 40% suspicious chance of thyroid cancer isn't true.He said it's about 25% still. Afirma said NEGATIVE for BRAF and Meduliary but still assigned a classification of "Suspicious" with 40% chance of cancer. These results do not change the risk of malignancy of the (ROM) of the Afirma GSC suspicious result." As I have learned on this board, just 'taking a pill' for the rest of your life isn't as easy as it sounds. official website and that any information you provide is encrypted I am still holding off on surgery for now. He tried to console me but he was also upset. Of the 343 nodules that underwent the GEC test, 178 cases (51.9%) were considered suspicious for cancer. 3) What do I need to know? One has tested benign on several FNAs, is cystic, and has remained consistent in size. Abigail. The positive predictive value of the GSC is 47.1%.1 Results Afirma GSC results may help guide surgical decision making in patients with thyroid nodules. 2018 Jul;126(7):471-480. doi: 10.1002/cncy.21993. Surgical margins: negative for tumor (tumor is < 0.1cm from margin) Seeking a second opinion I went to a leading hospital. Would you like email updates of new search results? The biopsy (Afirma) was indeterminate with GSC suspicious with a 50% ROM. Thyroseq v3, Afirma GSC, and microRNA Panels Versus Previous Molecular Tests in the Preoperative Diagnosis of Indeterminate Thyroid Nodules: A Systematic Review and Meta-Analysis.
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